Blumoo Universal RF Remote Control - $99.00 ($129.99)
There are many devices and apps that can turn your cell phone into a universal remote. What most of them don't give you, though, is audio streaming functionality in the same place. Blumoo's device lets you stream audio directly to your stereo and gives you a customized TV guide specific to your Cable subscription.
If your cellphone is always in your pocket, you'll never have to worry about losing the remote again.